Aditi Murthy

Inflammatory Fibroblasts Promote Repair After Injury Through Epithelial Proliferation

The paper identifies inflammatory fibroblasts that promote lung repair by enhancing epithelial proliferation through BMP signaling, validated across multiple models and human disease.

Divergent Pathways of Surfactant Protein C Maturation for Disease-Associated Isoforms

This study compares the maturation pathways of wild-type and disease-associated SP-C mutants, showing divergent trafficking and processing due to mutations.

REGULATORY T CELLS PROTECT AGAINST ABERRANT REMODELING IN A MOUSE MODEL OF PULMONARY FIBROSIS

This study shows that regulatory T cells (Tregs) protect against pulmonary fibrosis in a mouse model by reducing fibrosis and promoting tissue repair through immune-mesenchymal-epithelial signaling.

Impaired AMPK Control of Alveolar Epithelial Cell Metabolism Promotes Pulmonary Fibrosis

The paper identifies impaired AMPK signaling in AT2 cells as a driver of pulmonary fibrosis and shows restoring AMPK alleviates fibrosis in vivo.

Marginated neutrophils in the lungs effectively compete for nanoparticles targeted to the endothelium, serving as a part of the reticuloendothelial system

The paper shows that lung marginated neutrophils effectively uptake endothelial-targeted nanoparticles, suggesting they are part of the reticuloendothelial system.

Aberrant Transitional Alveolar Epithelial Cells Promote Pathogenic Activation of Lung Fibroblasts in Preclinical Fibrosis Modeling

This study identifies aberrant transitional alveolar epithelial cells in a mouse fibrosis model and shows they activate fibroblasts through a profibrotic secretome.

Disruption of Prostaglandin F2α Receptor Signaling Attenuates Fibrotic Remodeling and Alters Fibroblast Population Dynamics in A Preclinical Murine Model of Idiopathic Pulmonary Fibrosis

This study shows that disrupting PGF2α receptor signaling reduces fibrosis in a mouse model of IPF by altering fibroblast dynamics and reducing fibrotic endpoints.