Maria Ciocca Basil

The paper identifies KRT17-Stratifin complex as a protective barrier in dysplastic alveolar basaloid cells during chronic fibrosis, revealing mechanisms of alveolar metaplasia and its functional relevance.

The paper constructs a single-cell atlas of PVOD across the lifespan, identifying endothelial dysfunction and molecular pathways as key drivers of the disease with potential therapeutic targets.

This study shows that Z-AAT expression in AT2 cells causes stress responses and increases emphysema risk in AATD.

The paper creates a postnatal human lung developmental atlas to identify genes linked to chronic lung disease risk and shows COPD genetic risk is enriched in genes active during early postnatal endothelial development.

This study shows that alveolar epithelial type I cells propagate mechanical signals that affect lung homeostasis and disease states through intercellular communication.

This study maps the temporal sequence of mouse lung regeneration after viral injury, identifying persistent injury-associated cell states and their role in alveolar niche repair.

The paper identifies an injury-induced tissue niche (iTCH) in the lung that coordinates regenerative and disease responses through mesenchymal plasticity and signaling pathways.

The paper shows that lung marginated neutrophils effectively uptake endothelial-targeted nanoparticles, suggesting they are part of the reticuloendothelial system.

This study identifies aberrant transitional alveolar epithelial cells in a mouse fibrosis model and shows they activate fibroblasts through a profibrotic secretome.

The paper constructs a single-cell reference atlas for human and mouse lung tissues to improve cell type annotation and data integration.

The paper investigates how hyperactive mTOR in lung mesenchyme leads to endothelial dysfunction and pulmonary vascular remodeling in LAM.