Live-cell, single-molecule imaging resolves the dual nature of mRNA silencing by SARS-CoV-2 Nsp1
Adam C Koch, O’Neil Wiggan, Emry Burns, Brian J. Geiss, Christopher Davis Snow, Timothy J. Stasevich
This study uses live-cell imaging to show SARS-CoV-2 Nsp1 silences mRNAs by reducing their numbers through two cap-dependent mechanisms, while viral UTRs enhance translation but do not protect from Nsp1.
bioRxiv · Oct 30, 2026 · PreprintMolecular Biology