Author

Brian J. Geiss

Colorado State UniversityORCID 0000-0001-8180-5772Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 2 Molecular Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Approach:deep learning· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Christopher Davis SnowiD· 3 shared Timothy J. StasevichiD· 3 shared Brooke M. Enney· 2 shared Gregory D. EbeliD· 2 shared Jacob DeRooiD· 2 shared Ning ZhaoiD· 2 shared Adam C Koch· 1 shared Chasity E. TrammelliD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersMolecular Biology

Christopher Davis SnowORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Molecular BiologybioRxivPreprintOct 30, 2026

Live-cell, single-molecule imaging resolves the dual nature of mRNA silencing by SARS-CoV-2 Nsp1

Adam C Koch, O’Neil Wiggan, Emry Burns…·Timothy J. Stasevich

This study uses live-cell imaging to show SARS-CoV-2 Nsp1 silences mRNAs by reducing their numbers through two cap-dependent mechanisms, while viral UTRs enhance translation but do not protect from Nsp1.

DOI 10.64898/2026.10.23.759733

humanimaging

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Cell BiologyScience AdvancesPeer-reviewedJan 2, 2026

AI-assisted protein design to rapidly convert antibody sequences to intrabodies targeting diverse peptides and histone modifications

Gabriel Galindo, Daiki Maejima, Jacob DeRoo…·Timothy J. Stasevich

This paper presents an AI-driven method to convert antibody sequences into functional intrabodies, successfully converting 19 out of 26 sequences, including those targeting histone modifications.

14 citationstop 1%

protein sequencedeep learning

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MicrobiologybioRxivPreprintOct 31, 2025

Generation of broad-spectrum vaccine platforms against tick-borne flaviviruses using ancestral sequence reconstruction

Chasity E. Trammell, Brooke M. Enney, Michelle J. Savran…·Gregory D. Ebel

This study uses ancestral sequence reconstruction to design a vaccine platform against multiple tick-borne flaviviruses, showing broad protection in mice.

DOI 10.1101/2025.10.31.685878

mouseproteomics

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MicrobiologybioRxivPreprintJul 29, 2025

Development of ENTV reverse genetics system and phenotypic evaluation of rescued virus reveals host-specific replication patterns in mosquitoes

Marina Fujii, Emily N. Gallichotte, Irma Sánchez-Vargas…·Brian J. Geiss

This study develops an ENTV infectious clone and evaluates its replication in mosquito cells and mosquitoes, revealing host-specific replication patterns and midgut barriers to transmission.

DOI 10.1101/2025.07.29.667424

mouseexperimental assay

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Molecular BiologybioRxivPreprintApr 19, 2024

PAbFold: Linear Antibody Epitope Prediction using AlphaFold2

Jacob DeRoo, James S. Terry, Ning Zhao…·Brian J. Geiss

PAbFold predicts linear antibody epitopes using AlphaFold2 by modeling antibody-antigen complexes, showing accuracy on known targets and validating on a novel anti-SARS-CoV-2 antibody.

2 citations

protein structuredeep learning

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