Harnessing variation in Drosophila melanogaster reveals different routes to increased infection susceptibility over age and sex-dependent association with lifespan
Barbara Monteiro-Black, Mary-Kate Corbally, Julia Aleksandrowicz, Adam M Taggart, Francesco Langella, Rebecca L. Belmonte, Paulina Mika, David Duneau, Jennifer C. Regan
This study examines age-related increases in infection susceptibility in Drosophila melanogaster, finding that susceptibility rises early in life and is linked to reduced tolerance rather than resistance, with distinct effects on male lifespan.
bioRxiv · Jul 7, 2025 · PreprintImmunology