Jennifer C. Regan

Sex-specific regulation of macrophage function determines outcome to acute bacterial infection

This study shows that macrophage sex identity determines infection outcomes in Drosophila, with feminized male macrophages reducing susceptibility to S. aureus.

A divergent cyclic nucleotide binding protein promotes Plasmodium ookinete infection of the mosquito

This study identifies a cyclic nucleotide binding protein, CBP-O, essential for Plasmodium ookinete invasion of mosquitoes, revealing its role in transmitting malaria parasites.

Harnessing variation in Drosophila melanogaster reveals different routes to increased infection susceptibility over age and sex-dependent association with lifespan

This study examines age-related increases in infection susceptibility in Drosophila melanogaster, finding that susceptibility rises early in life and is linked to reduced tolerance rather than resistance, with distinct effects on male lifespan.

Ras inhibition by trametinib treatment in Drosophila attenuates gut pathology in females and extends lifespan in both sexes

This study shows trametinib treatment reduces gut pathology in female Drosophila and extends lifespan in both sexes by inhibiting Ras.