Resolving Inflammation: The Impact of Antiretroviral Therapy on Macrophage Traffic In and Out of the CNS.
Zoey K. Wallis, Cecily C. Midkiff, Miaoyun Zhao, Patrick Autissier, S Kim, Addison Q. Amadeck, Yiwei Wang, Maia Jakubowski, Tricia H. Burdo, Andrew D. Miller, Qingsheng Li, Xavier A. Alvarez, Robert V. Blair, Kenneth C. Williams
This study examines how antiretroviral therapy (ART) affects macrophage movement in and out of the CNS in SIV-infected macaques, showing ART reduces perivascular macrophage accumulation but not meningeal or choroid plexus macrophages.
PLoS Pathogens · Dec 1, 2025Peer-reviewedImmunology