SIRT5 acts in the tumor microenvironment via endothelial cell metabolism to support breast cancer growth
Anthony Max Chen, Issahy Cano, Qian Zhao, Pei-Yin Tsai, Elijah Bacchus, Sadhan Jana, Irma R. Fernandez, Zeribe C. Nwosu, Andrew D. Miller, Joeva J. Barrow, Hening Lin, Esak Lee, Robert S. Weiss
This study identifies SIRT5 as a regulator of endothelial cell metabolism in the tumor microenvironment, showing its role in supporting breast cancer growth through vascular function.
bioRxiv · Apr 13, 2026 · PreprintCancer Biology