Benoît Chassaing

The constitutive androstane receptor protects against metabolic dysfunction-associated steatotic liver disease through sex specific interactions with the gut microbiota

This study shows that the constitutive androstane receptor (CAR) protects against MASLD in males through interactions with gut microbiota, but not in females.

Type 6 secretion systems of adherent-invasive Escherichia coli isolated from Crohn's disease patients shape intestinal microbiota.

This study shows that T6SS genes are more prevalent in Crohn's disease patients' microbiota and functionally impact gut microbiota composition in mice.

The chemorepellent effect of metformin limits bacterial penetration into mammalian mucus by altering bacterial motility

This study shows metformin acts as a bacterial chemorepellent, reducing bacterial penetration into mucus by altering motility and chemotaxis.

Host-derived bile acids drive dysbiosis by selecting bile-resistant epimerizing bacteria in inflammatory bowel disease

The paper identifies epimerized host-derived bile acids as a driver of dysbiosis in IBD by selecting for bile-resistant bacteria that disrupt host bile acid feedback signaling.

Collective protection drives human gut microbiota response to amoxicillin treatment.

This study examines how human gut microbiotas respond to amoxicillin treatment using an in vitro model, finding that initial community composition and antibiotic inactivation dynamics influence resilience and resistance selection.

ILC3s are Required for Enterocyte Homeostasis to Food Intake

This study shows that ILC3s prevent post-prandial inflammation by regulating enterocyte metabolism during food intake.

Dietary emulsifiers and host inflammation synergistically drive genomic evolution of Crohn disease-associated E. coli toward enhanced pathogenicity

This study shows dietary emulsifiers and host inflammation together drive genomic changes in AIEC, increasing its pathogenicity.

Oral Fumarate-based drugs alter gut microbiota species via cysteine succination

This study shows fumarate-based drugs modify gut bacteria via cysteine succination, affecting their functions and interactions in both isolated cultures and microbial communities.

Decoding E. coli's Gut Survival Strategies: A CRISPRi Approach Across Diets, Inflammatory Environment and Strains

This study uses CRISPRi to identify genetic factors affecting E. coli adaptation across diets, inflammation, and strains in a mouse model.

Soluble and insoluble dietary fibres differentially affect liver steatosis and gut microbiota in western-diet fed mice

This study shows that soluble fiber inulin reduces liver fat and metabolic issues in mice on a Western diet, while insoluble fiber cellulose does not, suggesting inulin's benefits come from its effect on gut microbiota.

Perinatal Morphine Exposure Induces Long-Term Changes in the Intestinal Microbiota of Male and Female Rats

This study shows that perinatal morphine exposure in rats causes long-term intestinal microbiota changes that may affect immune system development and increase infection risk.

The gut insulin receptor acts as gatekeeper of intestinal barrier integrity

This study shows that gut insulin receptor loss increases intestinal permeability and susceptibility to infections by impairing Paneth cell function and intestinal stem cell homeostasis.

Maternal diet alters offspring early life host-microbiota communication through goblet cells, resulting in long-lasting diseases susceptibility

This study shows maternal diet affects offspring microbiota and health through goblet cells, leading to long-term disease susceptibility.

Effect of thermoneutral housing on MASLD severity, hepatic gene expression, and BAT activation during β3-adrenergic stimulation in mice

This study shows thermoneutral housing worsens MASLD in mice by increasing obesity, inflammation, fibrosis, and impairing BAT activation during β3-adrenergic stimulation.

Chronic dietary ingestion of Bacillus thuringiensis spores promotes intestinal inflammation and aging in non-target adult Drosophila

This study shows chronic Bt spore ingestion in Drosophila reduces lifespan, causes gut inflammation, and promotes aging.

Flagellin in the human gut microbiome is a diet-adjustable adjuvant for vaccination

This study shows that gut microbiome flagellin affects vaccine reactogenicity and can be influenced by diet.

Clostridioides difficile binary toxin CDT induces biofilm-like persisting microcolonies

This study shows that CDT toxin from Clostridioides difficile induces biofilm-like microcolonies, increasing colonization and persistence in intestinal models and infected mice.

The gut microbiome is associated with cocaine behavior and predicts addiction vulnerability in adult male rats

This study links gut microbiota composition to cocaine behavior in rats, showing that baseline microbial profiles predict addiction vulnerability.