A heterogeneous pharmaco-transcriptomic landscape induced by targeting a single oncogenic kinase
Ross M. Giglio, Nicholas Y. Hou, Lingting Shi, Adeya Wyatt, Justin Hong, Mathini Vaikunthan, Charlotte Bellamy, Henry Fuchs, Vivian Lu, Ndubuisi Obasi, Jose Pomarino Nima, Seth W. Malinowski, Keith Lloyd Ligon, José L. McFaline‐Figueroa, Nir Yosef, , Jose Ricardo McFaline-Figueroa
This study uses SCHEMATIC to analyze the molecular response of glioblastoma to EGFR inhibitors, identifying chemotype-specific programs and showing that combined EGFR/PI3K inhibition reduces adaptive transcription.
bioRxiv · Apr 8, 2024 · PreprintGenomics