NRF2 activation induces NADH-reductive stress providing a metabolic vulnerability in lung cancer
Tommy Weiss‐Sadan, Maolin Ge, Makiko Hayashi, Magdy Gohar, Cong-Hui Yao, Adriaan de Groot, Stefan Andrew Harry, Alexander Daniel Carlin, Hannah Fischer, Lei Shi, Ting-Yu Wei, Charles H. Adelmann, Konstantin M. P. Wolf, Tristan Vornbäumen, Benedikt R. Dürr, , Liron Bar‐Peled
The paper shows NRF2 activation in KEAP1 wildtype lung cancers causes NADH-reductive stress, making them vulnerable to Complex I inhibition.
Cell Metabolism · Feb 24, 2023Peer-reviewedMolecular Biology