Deep learning-based image quantification of epithelial cell shapes and its application to polycystic kidney disease
Johannes Jahn, Alexis Hofherr, Clara Consoli, Berenike Fajen, Rebekka Goll, Greta Theresa Liedtke, Adrian Boehm, Friederike Selbach, Paul Christoph Zeisler, Vanessa Weichselberger, Anne-Kathrin Classen, Lukas Westermann, Tilman Busch, Michael Köttgen
This paper develops a deep learning pipeline to quantify epithelial cell shape and tight junctions, applied to ADPKD models and Drosophila egg chambers to study morphogenetic changes.
bioRxiv · Aug 13, 2025 · PreprintBioinformatics