Tilman Busch

This study identifies biomechanical changes in the tubular basement membrane as drivers of cyst formation in ADPKD, linking cilia and polycystin-1 function.

This paper develops a deep learning pipeline to quantify epithelial cell shape and tight junctions, applied to ADPKD models and Drosophila egg chambers to study morphogenetic changes.

This study investigates DNAJB11's role in atypical ADPKD, showing biallelic loss causes cystic kidney disease and identifying impaired PC1 cleavage as a potential mechanism.