Alexis Hofherr

This study identifies an extra-ciliary role for polycystins in regulating Ezrin and renal tubular morphology through phosphorylation and localization changes.

This paper develops a deep learning pipeline to quantify epithelial cell shape and tight junctions, applied to ADPKD models and Drosophila egg chambers to study morphogenetic changes.

This study investigates DNAJB11's role in atypical ADPKD, showing biallelic loss causes cystic kidney disease and identifying impaired PC1 cleavage as a potential mechanism.

This study shows that Eomes and Brachyury control pluripotency exit and germ layer segregation by altering chromatin states, with Tbx factors repressing pluripotency and NE gene programs while enabling ME differentiation.