Mitochondrial protein import stress causes progressive neurodegeneration opposed by PERK - eIF2α signalling
Johannes Ebding, Marlene Barth, Lena Maria Lion, Adrian Gackstatter, Sarah Link, Marcello Pirritano, Gilles Gasparoni, Martin Simon, Johannes M. Herrmann, Jan Pielage
The paper shows that mitochondrial import stress causes neurodegeneration, which is opposed by PERK-eIF2α signaling, with PERK overexpression protecting against it.
bioRxiv · Apr 14, 2026 · PreprintNeuroscience