Jan Pielage

Mitochondrial protein import stress causes progressive neurodegeneration opposed by PERK - eIF2α signalling

The paper shows that mitochondrial import stress causes neurodegeneration, which is opposed by PERK-eIF2α signaling, with PERK overexpression protecting against it.

Loss of NudE-mediated dynein activation at synaptic terminals causes progressive axon length-dependent neurodegeneration

Protein phosphatase 4 is required for centrosome asymmetry in fly neural stem cells

This study shows that Protein phosphatase 4 (Pp4) is required for centrosome asymmetry in fly neural stem cells by regulating the relocalization of Centrobin and maintaining MTOC activity.

Optimized design and in vivo application of optogenetically functionalized Drosophila dopamine receptors

This paper optimizes optogenetically functionalized GPCRs to achieve specific in vivo neuromodulatory signaling in Drosophila, showing rescue of endogenous receptor function.

The cellular architecture of memory modules in Drosophila supports stochastic input integration

The paper models the Drosophila mushroom body to show how sparse synaptic connectivity enables efficient memory storage through stochastic input integration.

Integration of Odor-Induced Activity of Kenyon Cells in an Electrotonically Compact Drosophila Mushroom Body Output Neuron (MBON)

The paper models the integration of odor-induced activity in Drosophila MBON-3 by simulating synaptic inputs and shows its electrotonic compactness.