Human HPSE2 gene transfer ameliorates bladder pathophysiology in a mutant mouse model of urofacial syndrome.
Filipa M. Lopes, Céline Grenier, Benjamin W. Jarvis, Sara Al Mahdy, Adrian Lène-McKay, Alison M. Gurney, William G. Newman, Simon N. Waddington, Adrian S. Woolf, Neil A. Roberts
This paper demonstrates that AAV-mediated HPSE2 gene transfer improves bladder function in a mouse model of urofacial syndrome by restoring neurogenic relaxation.
eLife · Jul 11, 2024Peer-reviewedNeuroscience