Deformability screening identifies NUDT5 as a mediator of cellular mechanobiology
Angelina Flores, Jennifer Soto, Navjot Kaur Gill, Ahmed Almunaifi, Chau Ly, Dongping Qi, Ruchira Krishnamurthy, Eleana Parajón, Bobby Tofig, Valeria Garcia, María Sol Recouvreux, S Li, Yi Lu, Beth Y. Karlan, Douglas N. Robinson, , Amy C. Rowat
The paper screens compounds to identify mechanical mediators by measuring cell deformability, finding NUDT5 as a key mediator in ovarian cancer.
bioRxiv · Jul 16, 2026 · PreprintCell Biology