Douglas N. Robinson

This study uses a computational model to show that cell-cell adhesion has a greater impact on spheroid elasticity than single-cell stiffness, while both influence viscoelastic relaxation.

The paper screens compounds to identify mechanical mediators by measuring cell deformability, finding NUDT5 as a key mediator in ovarian cancer.

This study identifies cytoskeletal feedback loops that regulate Ras/PI3K signaling and cell polarity in Dictyostelium and neutrophils by modulating actin and myosin dynamics.

This study shows that Ras activity has a biphasic effect on cell migration, with both high and low activity impairing movement, and reveals that Ras regulates migration through rapid, non-transcriptional mechanisms.

The paper demonstrates symmetry breaking in an active protocellular system through externally-controlled actin polymerization in giant unilamellar vesicles.