Drug Metabolism and Transport Capacity of Endothelial Cells, Pericytes, and Astrocytes: Implications for CNS Drug Disposition
Hannah N. Wilkins, Stephen A. Knerler, Ahmed Warshanna, Rodnie Colón Ortiz, Kate Haas, Benjamin C. Orsburn, Dionna W. Williams
The paper evaluates drug metabolism and transport in BBB cell types, finding distinct capacities in endothelial cells, pericytes, and astrocytes that affect CNS drug disposition.
ACS Pharmacology & Translational Science · Oct 18, 2024Peer-reviewedPharmacology & Toxicology