Author

Rodnie Colón Ortiz

Johns Hopkins UniversityORCID 0000-0002-3977-1019Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Pharmacology & Toxicology· 2 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2 Organism:rat· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Dionna W. WilliamsiD· 3 shared Hannah N. WilkinsiD· 3 shared Stephen A. Knerler· 3 shared A C PriceiD· 2 shared Alicia MercadoiD· 2 shared Benjamin C. OrsburniD· 2 shared Jose J. Rosado‐FrancoiD· 2 shared Ahmed Warshanna· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersPharmacology & Toxicology

Dionna W. WilliamsORCID

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3 papers

Recent·Most cited

Primary Human Macrophages Exhibit Functional CYP3A4 Activity with Marked Expression-Function Discordance and Cocaine-Induced Catalytic Activation

A C Price, Stephen A. Knerler, Rodnie Colón Ortiz, Jareb J. Pérez-Caraballo, Alysha L. Ellison, Cory J. White, Jose J. Rosado‐Franco, Hannah N. Wilkins, Alicia Mercado, Kiara Mehta, Oluwatofunmi Oteju, Parker K. Stevenson, Kimberly S. Williams, Peter J. Gaskill, Dionna W. Williams

This study shows human macrophages have functional CYP3A4 activity, with expression and function discordance, and cocaine increases CYP3A4 activity across donors.

bioRxiv · Oct 25, 2026 · PreprintPharmacology & Toxicology

Drug Metabolism and Transport Capacity of Endothelial Cells, Pericytes, and Astrocytes: Implications for CNS Drug Disposition

Hannah N. Wilkins, Stephen A. Knerler, Ahmed Warshanna, Rodnie Colón Ortiz, Kate Haas, Benjamin C. Orsburn, Dionna W. Williams

The paper evaluates drug metabolism and transport in BBB cell types, finding distinct capacities in endothelial cells, pericytes, and astrocytes that affect CNS drug disposition.

ACS Pharmacology & Translational Science · Oct 18, 2024Peer-reviewedPharmacology & Toxicology

Cocaine Regulates Antiretroviral Therapy CNS Access Through Pregnane-X Receptor-Mediated Drug Transporter and Metabolizing Enzyme Modulation at the Blood Brain Barrier

Rodnie Colón Ortiz, Stephen A. Knerler, Lisa B. Fridman, Alicia Mercado, A C Price, Jose J. Rosado‐Franco, Hannah N. Wilkins, Bianca R. Flores, Benjamin C. Orsburn, Dionna W. Williams

This study investigates how cocaine affects the transport and metabolism of antiretroviral drugs across the blood-brain barrier by modulating drug transporters and enzymes.

Fluids and Barriers of the CNS · Jan 10, 2024Peer-reviewedNeuroscience