Benjamin C. Orsburn

Aging, HIV Status, and Sex Differentially Influence Antiretroviral Therapy Disposition Pathways in Rectosigmoid Tissue and Peripheral Blood Mononuclear Cells

This study identifies how aging and HIV status differentially affect antiretroviral therapy disposition pathways in rectosigmoid tissue and PBMC, with aging causing broader changes in drug-related proteins.

A Parallel Accumulation-Mobility Aligned Fragmentation Strategy Utilizing High-Resolution Ion Mobility for High Performance Proteomics Analysis

This paper introduces PAMAF, a novel DIA-MS mode using HRIM for proteomics, achieving higher sensitivity and efficiency in protein identification and quantification.

Backyard proteomics: A case study with the black widow spider

This paper demonstrates that proteomic analysis is feasible for less studied organisms like black widow spiders using available genome annotations and ortholog mapping.

Drug Metabolism and Transport Capacity of Endothelial Cells, Pericytes, and Astrocytes: Implications for CNS Drug Disposition

The paper evaluates drug metabolism and transport in BBB cell types, finding distinct capacities in endothelial cells, pericytes, and astrocytes that affect CNS drug disposition.

The carrier proteome limit should be reassessed for each mass analyzer architecture

The study shows that carrier proteome limits vary with mass analyzer type, suggesting that using analyzers with higher linear dynamic range can improve isobaric peptide signal amplification.

Cocaine Regulates Antiretroviral Therapy CNS Access Through Pregnane-X Receptor-Mediated Drug Transporter and Metabolizing Enzyme Modulation at the Blood Brain Barrier

This study investigates how cocaine affects the transport and metabolism of antiretroviral drugs across the blood-brain barrier by modulating drug transporters and enzymes.

Bolt: A new age peptide search engine for comprehensive MS/MS sequencing through vast protein databases in minutes.

Bolt is a proteomics search engine that rapidly processes large protein databases with enhanced sensitivity and accuracy for MS/MS sequencing.

Direct Measurement of Synchronous Precursor Selection (SPS) Accuracy in Public Proteomics Datasets

The paper assesses the accuracy of synchronous precursor selection (SPS) in proteomics datasets using a new post-processing tool applied to three public datasets.

Reporter Ion Data Analysis Reduction (R.I.D.A.R) for isobaric proteomics quantification studies

The paper introduces RIDAR, a method to reduce computational load in isobaric proteomics by filtering MS/MS spectra before database searching, achieving an 85% time reduction on a standard desktop.