Dionna W. Williams

This study identifies how aging and HIV status differentially affect antiretroviral therapy disposition pathways in rectosigmoid tissue and PBMC, with aging causing broader changes in drug-related proteins.

This study shows human macrophages have functional CYP3A4 activity, with expression and function discordance, and cocaine increases CYP3A4 activity across donors.

This study shows chronic THC vapor exposure in rats affects brain endocannabinoid and immune systems but not peripheral organs, leading to gut microbiota changes and altered metabolites.

This study shows CBD reduces viral replication and immune activation in HIV/SIV models, suggesting it could be a useful adjunct to antiretroviral therapy.

This study examines how SIV infection and ART affect lipid distribution in rhesus macaque brains, showing ART increases phospholipids while SIV impacts vary by brain region.

The paper evaluates drug metabolism and transport in BBB cell types, finding distinct capacities in endothelial cells, pericytes, and astrocytes that affect CNS drug disposition.

This study investigates how cocaine affects the transport and metabolism of antiretroviral drugs across the blood-brain barrier by modulating drug transporters and enzymes.

The paper evaluates gene expression of endocannabinoid receptors across species and organs, revealing limited cross-species overlap and highlighting challenges in translational research.