Eggerthella lenta evades bacteriophage through reversible megabase-scale inversions of capsular polysaccharide gene clusters
Peter James Turnbaugh, Shenwei Zhang, Colin Buttimer, Kai R. Trepka, Kathy Lam, Luis Raminrez Hernandez, Cecilia A. Noecker, Paola Soto-Perez, Paolo Canigiula, Edwin Ortega, Jenny Lee, Lorenzo Ramirez, Gina Partipilo, Hugh Lawrence, Francesca Bottacini, , Colin Hill
This study identifies a phage-resistant sub-population of Eggerthella lenta in mice, linked to reversible genomic inversions and altered capsule production.
bioRxiv · Apr 25, 2026 · PreprintMicrobiology