Kai R. Trepka

This study shows diet changes during cancer chemotherapy affect gut microbiome composition and diversity, with specific nutrients linked to microbial shifts and toxicity.

This study identifies a phage-resistant sub-population of Eggerthella lenta in mice, linked to reversible genomic inversions and altered capsule production.

The paper isolates and analyzes E. lenta genomes, revealing a distinct lineage associated with inflammation and highlighting its population structure and functional diversity.

The paper analyzes microbiome data from multiple cohorts to identify consistent signatures associated with methotrexate response in rheumatoid arthritis patients.

The paper identifies a female-enriched gut bacterium, Eggerthella lenta, that drives neuroinflammation and IFN-γ via TLR2 in autoimmune disease models.

The paper introduces PAMA-seq, a method for cross-domain microbial taxonomic profiling, validated on synthetic and real samples, showing improved accuracy and efficiency over existing methods.

This study shows gut bacteria produce lactate that increases lung epithelial mitochondrial activity and worsens acute lung injury.

The paper shows that a bacterial operon in the gut microbiome can reduce drug toxicity during cancer treatment by inactivating 5-fluorouracil.