Improved Protein Semi-Synthesis Enables Biophysical Studies of Thioamide Destabilization of β-Sheet Interactions
Evan S. K. Yanagawa, Kristen E. Fiore, Denver Y. Francis, Aiden Lesneski, Yanan Chang, Benjamin W. Roose, David W. Christianson, Kohei Sato, E. James Petersson
This paper develops a method to synthesize thioamide-containing proteins and shows they destabilize β-sheet structures in GB1 and α-synuclein fibrils.
Biochemistry · Aug 19, 2026Peer-reviewedBiochemistry