Author

Benjamin W. Roose

Merck & Co., Inc., Rahway, NJ, USA (United States)ORCID 0000-0003-3333-5053Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Research Focus:drug response / drug discovery· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

Matthew W. SchombsiD· 2 shared Aiden Lesneski· 1 shared Alyssa Q. StivingiD· 1 shared Ashley Gruber· 1 shared Christopher M. TubbsiD· 1 shared David W. ChristiansoniD· 1 shared Denver Y. Francis· 1 shared E. James PeterssoniD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersBiochemistry

Matthew W. SchombsORCID

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3 papers

Recent·Most cited

BiochemistrybioRxivPreprintSep 11, 2026

Analytical evaluation of eukaryotic cell-free translation (CFT) systems to assess mRNA translatability

Benjamin W. Roose, Pankaj Dwivedi, Matthew W. Schombs

This paper evaluates three eukaryotic cell-free translation systems to determine their suitability for assessing mRNA translatability in vaccine development.

DOI 10.64898/2026.09.09.750399

humanexperimental assay

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BiochemistryBiochemistryPeer-reviewedAug 19, 2026

Improved Protein Semi-Synthesis Enables Biophysical Studies of Thioamide Destabilization of β-Sheet Interactions

Evan S. K. Yanagawa, Kristen E. Fiore, Denver Y. Francis…·E. James Petersson

This paper develops a method to synthesize thioamide-containing proteins and shows they destabilize β-sheet structures in GB1 and α-synuclein fibrils.

DOI 10.1021/acs.biochem.6c00371

protein structureexperimental assay

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Biochemistrynpj VaccinesPeer-reviewedFeb 23, 2025

Enabling functionality and translation fidelity characterization of mRNA-based vaccines with a platform-based, antibody-free mass spectrometry detection approach

Alyssa Q. Stiving, Benjamin W. Roose, Christopher M. Tubbs…·Xuanwen Li

This paper develops an antibody-free mass spectrometry method to assess mRNA vaccine functionality and translation fidelity using cell-free translation and LC-MS.

15 citations

humanproteomics

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