Author

Kristen E. Fiore

University of PennsylvaniaORCID 0000-0002-8527-5657Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:protein folding & dynamics· 2 Assay:protein structure· 2 Approach:biophysical modeling· 1 Approach:experimental assay· 1

Frequent Co-Authors

Denver Y. Francis· 2 shared E. James PeterssoniD· 2 shared Aiden Lesneski· 1 shared Benjamin W. RooseiD· 1 shared David W. ChristiansoniD· 1 shared Evan S. K. Yanagawa· 1 shared Kohei SatoiD· 1 shared Ryann M. PereziD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBiochemistry

Denver Y. Francis

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2 papers

Recent·Most cited

Improved Protein Semi-Synthesis Enables Biophysical Studies of Thioamide Destabilization of β-Sheet Interactions

Evan S. K. Yanagawa, Kristen E. Fiore, Denver Y. Francis, Aiden Lesneski, Yanan Chang, Benjamin W. Roose, David W. Christianson, Kohei Sato, E. James Petersson

This paper develops a method to synthesize thioamide-containing proteins and shows they destabilize β-sheet structures in GB1 and α-synuclein fibrils.

Biochemistry · Aug 19, 2026Peer-reviewedBiochemistry

Modulation of SpyCatcher Ligation Kinetics by SpyTag Thioamide Substitution

Kristen E. Fiore, Denver Y. Francis, Sobrielle M. Casimir, Ryann M. Perez, E. James Petersson

This study investigates how thioamide substitutions in SpyTag affect ligation kinetics with SpyCatcher, showing both faster and slower complex formation depending on substitution position.

bioRxiv · Oct 10, 2024 · PreprintBiochemistry