Succinate enhances mitochondrial metabolism and phagocytosis in human airspace monocytes
Karen Slattery, Aisling Newing, John Joseph McGrath, Albert Sanfeliu, Oisín O’Gallchobhair, Lynne Faherty, Emma McNally, Finbar O’Connell, Parthiban Nadarajan, Patrick Mitchel, Seamas C. Donnelly, Suzanne M. Cloonan, Joseph Keane, Laura E. Gleeson
The paper identifies mitochondrial metabolism as a key regulator of phagocytic function in human lung monocytes and macrophages, showing that succinate supplementation enhances these functions and promotes macrophage differentiation.
bioRxiv · Jun 12, 2025 · PreprintImmunology