Author

Parthiban Nadarajan

St. James's HospitalORCID 0000-0002-1685-1876Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

Joseph KeaneiD· 3 shared Dearbhla M MurphyiD· 2 shared Donal J CoxiD· 2 shared Emily DuffiniD· 2 shared Laura E. GleesoniD· 2 shared Oisin Ó Gallchobhair· 2 shared Olivia Sandby Thomas· 2 shared Sharee A. BasdeoiD· 2 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersImmunology

Joseph KeaneORCID

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Author profile →

3 papers

Recent·Most cited

Dexamethasone impairs glycolysis but improves mycobacterial killing in primary human macrophages

Lorraine Thong, Olivia Sandby Thomas, Oisin Ó Gallchobhair, Emily Duffin, Anjali S Yennemadi, Gina R. Leisching, Dearbhla M Murphy, Parthiban Nadarajan, Fiona O’ Connell, Mary P O’Sullivan, Sharee A. Basdeo, Donal J Cox, Joseph Keane

This study shows dexamethasone reduces glycolysis in human macrophages but enhances mycobacterial killing, suggesting a potential therapeutic benefit in tuberculosis.

bioRxiv · Jun 27, 2025 · PreprintImmunology

Succinate enhances mitochondrial metabolism and phagocytosis in human airspace monocytes

Karen Slattery, Aisling Newing, John Joseph McGrath, Albert Sanfeliu, Oisín O’Gallchobhair, Lynne Faherty, Emma McNally, Finbar O’Connell, Parthiban Nadarajan, Patrick Mitchel, Seamas C. Donnelly, Suzanne M. Cloonan, Joseph Keane, Laura E. Gleeson

The paper identifies mitochondrial metabolism as a key regulator of phagocytic function in human lung monocytes and macrophages, showing that succinate supplementation enhances these functions and promotes macrophage differentiation.

bioRxiv · Jun 12, 2025 · PreprintImmunology

Human airway macrophages are metabolically reprogrammed by IFN-γ resulting in glycolysis dependent functional plasticity.

Donal J Cox, Sarah A Connolly, Cilian Ó Maoldomhnaigh, Aenea AI Brugman, Olivia Sandby Thomas, Emily Duffin, Karl M Gogan, Oisin Ó Gallchobhair, Dearbhla M Murphy, Sinead A O’Rourke, Finbarr O’Connell, Parthiban Nadarajan, James Joseph Phelan, Laura E. Gleeson, Sharee A. Basdeo, Joseph Keane

This study shows that human airway macrophages reprogram their metabolism in response to IFN-γ, leading to glycolysis-dependent functional plasticity that differs from monocyte-derived macrophages.

eLife · Jun 20, 2024Peer-reviewedImmunology