Albert Sanfeliu

This study uses snRNA-seq to analyze gene expression changes in the hippocampus of CDKL5-deficient mice, identifying cell-type-specific transcriptional alterations and intercellular signaling changes.

The paper uses transcriptomic data from SEEG electrodes to characterize the molecular microenvironment in human epilepsy, showing gene expression reflects local brain activity and cell types.

The paper identifies mitochondrial metabolism as a key regulator of phagocytic function in human lung monocytes and macrophages, showing that succinate supplementation enhances these functions and promotes macrophage differentiation.

This study uses explanted SEEG electrodes to integrate RNA sequencing, DNA methylation, and genomic data with electrophysiological recordings, revealing distinct molecular landscapes in epilepsies and identifying potential seizure zones.

This study identifies miR-335-5p as a regulator of voltage-gated sodium channels, showing that its modulation can influence seizure activity in epilepsy models.

The paper identifies MeCP2 target genes associated with multiple brain disorders and shows they share common molecular mechanisms in neuronal transmission, immunity, and development.