Laura E. Gleeson

This study compares monocyte phenotypes, function, and metabolism in latent TB infection, active TB disease, and healthy controls, finding distinct metabolic and cytokine profiles that differentiate the conditions.

The paper identifies mitochondrial metabolism as a key regulator of phagocytic function in human lung monocytes and macrophages, showing that succinate supplementation enhances these functions and promotes macrophage differentiation.

This study shows that human airway macrophages reprogram their metabolism in response to IFN-γ, leading to glycolysis-dependent functional plasticity that differs from monocyte-derived macrophages.