Suppression of DSB Formation by Polβ in Active DNA Demethylation is Required for Postnatal Hippocampal Development
Akiko Uyeda, Kohei Onishi, Teruyoshi Hirayama, Satoko Hattori, Tsuyoshi Miyakawa, Takeshi Yagi, Nobuhiko Yamamoto, Noriyuki Sugo
This study shows that Polβ suppresses DNA double-strand breaks during active DNA demethylation in postnatal hippocampal development, which is essential for proper neuronal differentiation and behavior.
bioRxiv · Nov 24, 2019 · PreprintNeuroscience