Satoko Hattori

The paper demonstrates that baseline-normalized metrics are essential for accurately interpreting fear memory in mice, showing that conventional freezing scores confound locomotor activity.

The paper uses spatial proteomics to identify projection-specific molecular diversity in the prefrontal cortex and identifies BLTP2 as a key presynaptic protein involved in memory and behavior.

The paper investigates brain pH and lactate levels in animal models of neuropsychiatric disorders, finding decreased pH and increased lactate levels as common features across multiple models.

This study shows that Polβ suppresses DNA double-strand breaks during active DNA demethylation in postnatal hippocampal development, which is essential for proper neuronal differentiation and behavior.