Takeshi Yagi

Large-scale dimensional behavioral profiling dissociates fear memory from locomotor confounds in mice: The necessity of baseline-normalized metrics

The paper demonstrates that baseline-normalized metrics are essential for accurately interpreting fear memory in mice, showing that conventional freezing scores confound locomotor activity.

Visualization of stochastic expression of clustered protocadherin β isoforms in vivo

The paper develops cPcdhβ reporter mouse lines to visualize stochastic expression of cPcdhβ isoforms in vivo and identifies patterns such as cell-type selectivity and developmental regulation.

Rhythm Receptive Fields in Striatum of Mice Executing Complex Continuous Movement Sequences

The paper investigates rhythm receptive fields in the striatum of mice performing complex movements, finding neurons sensitive to movement rhythm parameters and highlighting their role in motor coordination.

Visualization of trans homophilic interaction of clustered protocadherin in neurons

The paper visualizes homophilic interactions of clustered protocadherin in neurons using a novel FRET probe and finds that these interactions occur at contact sites between neurites and are stable, while synapses show rare homophilic interactions.

Imbalanced expression of clustered protocadherins in pre- and post-synaptic compartments of CA1 pyramidal cells during hippocampal development

The paper examines the localization of cPcdhγ proteins in pre- and post-synaptic compartments of hippocampal CA1 pyramidal cells and finds an imbalance in their expression.

Suppression of DSB Formation by Polβ in Active DNA Demethylation is Required for Postnatal Hippocampal Development

This study shows that Polβ suppresses DNA double-strand breaks during active DNA demethylation in postnatal hippocampal development, which is essential for proper neuronal differentiation and behavior.