Xavier Parés

A covalent irreversible inhibitor binds in two mutually exclusive conformations to the active-site cysteine residue of human aldehyde dehydrogenase 1A3

This paper identifies a covalent irreversible inhibitor, Z34, that binds to ALDH1A3 in two distinct conformations at the active-site cysteine, showing promise for anticancer drug development.

A sensitive fluorometric assay to detect aldo-keto reductase and carbonyl reductase activity based on a naphthaldehyde derivative

This paper introduces a fluorometric assay for detecting reductase activity using MONOL-41, showing improved sensitivity and lower detection limits compared to NADPH-based methods.

ALDH1 subtype-specific inhibitor targets key cancerous epithelial cell populations in aggressive subtypes of breast cancer

This study identifies ALDH1A3 as a therapeutic target in aggressive breast cancers and develops ABD0171, a selective inhibitor showing antitumor and antimetastatic effects.