Improving the clinical performance of blood-based DNA methylation biomarkers utilizing locus-specific epigenetic heterogeneity
Brendan Miller, Thomas R. Pisanic, Gennady Margolin, Hanna M. Petrykowska, Pornpat Athamanolap, Alexander Goncearenco, Akosua Osei-Tutu, Christina M. Annunziata, Tza‐Huei Wang, Laura L. Elnitski
This paper develops EpiClass, a methylation density-based classifier that improves the performance of blood-based DNA methylation biomarkers in detecting ovarian cancer by leveraging locus-specific epigenetic heterogeneity.
Clinical Epigenetics · Oct 20, 2020Peer-reviewedBioinformatics