Tza-Huei Wang

An Accessible and Scalable Pipette-Driven Microfluidic Platform for Lipid Nanoparticle Formulation

This paper introduces a microfluidic platform for lipid nanoparticle formulation that improves scalability and efficiency in mRNA delivery.

Crosslinking of Lipid Nanoparticles Enhances the Delivery Efficiency and Efficacy of mRNA Vaccines

This paper introduces a crosslinking method to improve mRNA LNP stability and delivery efficiency, showing enhanced structural integrity and transfection performance in vitro and in vivo.

Controlling Payload Heterogeneity in Lipid Nanoparticles for RNA-Based Therapeutics

This study identifies the causes of payload heterogeneity in lipid nanoparticles and proposes methods to improve RNA distribution uniformity.

Development of a Human iPSC-Derived "Corticospinal Tract-on-a-Chip" for Neurodegenerative Disease Research

This paper develops a human iPSC-derived microfluidic platform to model corticospinal tract connectivity and pathology for neurodegenerative disease research.

Improving the clinical performance of blood-based DNA methylation biomarkers utilizing locus-specific epigenetic heterogeneity

This paper develops EpiClass, a methylation density-based classifier that improves the performance of blood-based DNA methylation biomarkers in detecting ovarian cancer by leveraging locus-specific epigenetic heterogeneity.

Single-Cell Transcriptomic Analysis Reveals Molecular Diversity of Human Oligodendrocyte Progenitor Cells

The paper uses single-cell transcriptomics to analyze human oligodendrocyte progenitor cells, revealing transcriptional heterogeneity and pathways involved in their differentiation.

A novel platform to accelerate antimicrobial susceptibility testing in Neisseria gonorrhoeae using RNA signatures

This paper presents an RNA signature-based platform for rapid antimicrobial susceptibility testing of Neisseria gonorrhoeae using RNA markers validated across multiple isolates.