Single-cell spatial analysis of pediatric high-grade glioma reveals a novel population of SPP1+/GPNMB+ myeloid cells with immunosuppressive and tumor-promoting capabilities
Thijs J M van den Broek, Raoull Hoogendijk, Mariëtte E.G. Kranendonk, Julie A S Lammers, Akshaya L Krishnamoorthy, Ravian L. van Ineveld, Milo Molleson, Vasily O. Tsvetkov, Femke C. A. S. Ringnalda, Marc van de Wetering, Yan Su, John I. Bianco, Cristian Ruiz-Moreno, Mario G. Ries, Eelco Wieger Hoving, , Anoek Zomer
The paper uses single-cell spatial analysis to identify SPP1+/GPNMB+ myeloid cells in pediatric high-grade gliomas that suppress CD8+ T cells and promote tumor growth.
Neuro-Oncology Pediatrics · Jul 1, 2025Peer-reviewedCancer Biology