Cancer BiologyNeuro-Oncology PediatricsPeer-reviewed
Single-cell spatial analysis of pediatric high-grade glioma reveals a novel population of SPP1+/GPNMB+ myeloid cells with immunosuppressive and tumor-promoting capabilities
Thijs J M van den Broek, Raoull Hoogendijk, Mariëtte E.G. Kranendonk…·Anoek Zomer
The paper uses single-cell spatial analysis to identify SPP1+/GPNMB+ myeloid cells in pediatric high-grade gliomas that suppress CD8+ T cells and promote tumor growth.
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