Author

Thijs J M van den Broek

Princess Máxima CenterORCID 0000-0003-3034-6160Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:cell type annotation· 3 Organism:human· 3 Research Focus:cell-cell communication· 2 Approach:experimental assay· 2 Assay:spatial transcriptomics· 2 Assay:bulk RNA-seq· 1 Research Focus:clustering· 1 Approach:deep learning· 1

Frequent Co-Authors

Anne C. RiosiD· 3 shared Cristian Ruiz-MorenoiD· 3 shared Hendrik G. StunnenbergiD· 3 shared Mariëtte E.G. KranendonkiD· 3 shared Anoek ZomeriD· 2 shared Dannis Gilbert van VuurdeniD· 2 shared Eelco Wieger HovingiD· 2 shared Ellen J. WehrensiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

Anne C. RiosORCID

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3 papers

Recent·Most cited

Cancer BiologybioRxivPreprintJan 25, 2026

Cancer-myeloid cell invasive program in pediatric-type diffuse high-grade glioma

Cristian Ruiz-Moreno, Raphaël V U Collot, Thijs J M van den Broek…·Hendrik G. Stunnenberg

This paper presents an integrative multimodal atlas of pediatric-type diffuse high-grade gliomas, identifying cancer-myeloid cell programs and distinct cancer cell states across multiple patients.

2 citations

humanscRNA-seq

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Cancer BiologyNature CancerPeer-reviewedJan 5, 2026

De novo H3.3K27M-altered Diffuse Midline Glioma in human brainstem organoids to dissect GD2 CAR T cell function

Nils Bessler, Amber K. L. Wezenaar, Hendrikus CR Ariese…·Anne C. Rios

This paper develops a human brainstem organoid model of H3.3K27M-altered DMG to study GD2 CAR T cell function and identify therapeutic targets.

15 citationstop 1%

humanorganoid / primary culture

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Cancer BiologyNeuro-Oncology PediatricsPeer-reviewedJul 1, 2025

Single-cell spatial analysis of pediatric high-grade glioma reveals a novel population of SPP1+/GPNMB+ myeloid cells with immunosuppressive and tumor-promoting capabilities

Thijs J M van den Broek, Raoull Hoogendijk, Mariëtte E.G. Kranendonk…·Anoek Zomer

The paper uses single-cell spatial analysis to identify SPP1+/GPNMB+ myeloid cells in pediatric high-grade gliomas that suppress CD8+ T cells and promote tumor growth.

5 citations

humanspatial transcriptomics

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