Author

Femke C. A. S. Ringnalda

Princess Máxima CenterORCID 0000-0002-0684-4613Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Assay:spatial transcriptomics· 2 Research Focus:differential expression· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Marc van de WeteringiD· 2 shared Akshaya L Krishnamoorthy· 1 shared Anne C. RiosiD· 1 shared Anoek ZomeriD· 1 shared Antonin MarchaisiD· 1 shared Bernadette Liegl‐AtzwangeriD· 1 shared Branka Radic-SarikasiD· 1 shared Christian BerkiD· 1 shared

Activity by Year

2018-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersCancer Biology

Marc van de WeteringORCID

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Author profile →

3 papers

Recent·Most cited

A human lung organoid co-culture model of early bone sarcoma metastasis reveals contact-dependent epithelial remodeling at the metastatic interface

Martha Magdalena Zylka, Tümay Capraz, Gaël Moquin‐Beaudry, Christoph Hafemeister, Nikolina Bradaric, Lukas Watzke, Veveeyan Suresh, Ulrike M. Mann, Femke C. A. S. Ringnalda, Marco Wachtel, Matthias S. Dettmer, Corentin Thuilliez, Matthias Farlik, Helena Sorger, Antonin Marchais, , Branka Radic-Sarikas

This paper introduces a 3D co-culture model of bone sarcoma metastasis in the lung and identifies a contact-dependent epithelial remodeling response with potential therapeutic targets.

bioRxiv · Jun 8, 2026 · PreprintCancer Biology

Single-cell spatial analysis of pediatric high-grade glioma reveals a novel population of SPP1+/GPNMB+ myeloid cells with immunosuppressive and tumor-promoting capabilities

Thijs J M van den Broek, Raoull Hoogendijk, Mariëtte E.G. Kranendonk, Julie A S Lammers, Akshaya L Krishnamoorthy, Ravian L. van Ineveld, Milo Molleson, Vasily O. Tsvetkov, Femke C. A. S. Ringnalda, Marc van de Wetering, Yan Su, John I. Bianco, Cristian Ruiz-Moreno, Mario G. Ries, Eelco Wieger Hoving, , Anoek Zomer

The paper uses single-cell spatial analysis to identify SPP1+/GPNMB+ myeloid cells in pediatric high-grade gliomas that suppress CD8+ T cells and promote tumor growth.

Neuro-Oncology Pediatrics · Jul 1, 2025Peer-reviewedCancer Biology

Covalent linkage of the DNA repair template to the CRISPR/Cas9 complex enhances homology-directed repair

Nataša Savić, Femke C. A. S. Ringnalda, Helen A. Lindsay, Christian Berk, Katja Bargsten, Yizhou Li, Dario Neri, Mark D. Robinson, Constance Ciaudo, Jonathan Hall, Martin Jínek, Gerald Schwank

This study shows that covalently linking a DNA repair template to the CRISPR/Cas9 complex increases HDR efficiency 23-fold compared to NHEJ.

eLife · May 29, 2018Peer-reviewedMolecular Biology