A Comprehensive Multi-Center Cross-platform Benchmarking Study of Single-cell RNA Sequencing Using Reference Samples
Wanqiu Chen, Yongmei Zhao, Xin Chen, Zhaowei Yang, Xiaojiang Xu, Yingtao Bi, Vicky Chen, Jing Li, Hannah Choi, Ben Ernest, Bao Quoc Tran, Monika Mehta, Parimal Kumar, Andrew A. Farmer, Alain A. Mir, , Charles Wang
This study benchmarks scRNA-seq reproducibility across platforms and pipelines, finding that batch correction methods significantly affect results.
Nature Biotechnology · Dec 21, 2020Peer-reviewedGenomics