Author

Anja Mezger

Science for Life LaboratoryORCID 0000-0002-7337-9547Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 5 Research Focus:benchmarking· 2 Research Focus:gene regulatory network inference· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1

Frequent Co-Authors

William James GreenleafiD· 3 shared Arwa S. Kathiria· 2 shared Jörg A. BachmanniD· 2 shared Orlando Contreras‐LópeziD· 2 shared Sandy L. KlemmiD· 2 shared Abrahan Hernández‐HernándeziD· 1 shared Agrima BhattiD· 1 shared Alain A. Mir· 1 shared

Activity by Year

2018-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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3 shared papersGenomics

William James GreenleafORCID

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Author profile →

7 papers

Recent·Most cited

Comparative analysis of whole genome amplification kits for single-cell genome analysis

Abrahan Hernández‐Hernández, Pontus Höjer, Michelle Ljungmark, Anastasios Glaros, Eunkyoung Choi, Julia Hauenstein, Nicolai Sebastian Frengen, Susanne Björnerfeldt, Camilla Enström, Robert Månsson, Jessica Nordlund, Anja Mezger

This study compares two WGA kits for single-cell genome analysis, finding that PTA/ResolveDNA outperforms MDA/REPLI-g in quality metrics and CNV detection.

bioRxiv · Oct 30, 2025 · PreprintGenomics

Isoform-Level Analysis of 10x Genomics Single-Cell cDNA Libraries from Cultured K562 Cells Using Long-Read Sequencing

Jörg A. Bachmann, Remi‐André Olsen, Agrima Bhatt, Nick Crang, Orlando Contreras‐López, Anja Mezger

The paper compares three methods for long-read sequencing of 10x Genomics single-cell cDNA libraries to evaluate their performance in full-length transcript capture, barcode identification, and isoform detection.

bioRxiv · Aug 12, 2025 · PreprintGenomics

Adapter dilution and input optimisation for Qiagen QIAseq miRNA Library kit

Fahri Azhari Hasby, Jörg A. Bachmann, Chuan Wang, Orlando Contreras‐López, Anja Mezger

The paper optimizes RNA input and adapter dilution strategies to reduce adapter dimers in miRNA sequencing using the QIAseq miRNA Library kit, improving data quality.

bioRxiv · Apr 30, 2025 · PreprintGenomics

Pooled optical screens in human cells

David Feldman, Avtar K Singh, Jonathan Leo Schmid-Burgk, Rebecca J. Carlson, Anja Mezger, Anthony J. Garrity, Feng Zhang, Paul C. Blainey

The paper introduces an optical method to link genetic perturbations with phenotypic outcomes in a pooled setting, identifying novel regulators of immune responses.

Cell · Oct 1, 2019Peer-reviewedGenomics

Landscape of stimulation-responsive chromatin across diverse human immune cells

Diego Calderon, Michelle Ly Thai Nguyen, Anja Mezger, Arwa S. Kathiria, Fabian Müller, Vinh Q. Nguyen, Ninnia Lescano, Beijing Wu, John J. Trombetta, Jessica V. Ribado, David A. Knowles, Ziyue Gao, Franziska Blaeschke, Audrey V. Parent, Trevor D. Burt, , Jonathan K. Pritchard

The paper maps stimulation-responsive chromatin changes in immune cells and identifies variants linked to autoimmunity.

Nature Genetics · Sep 30, 2019Peer-reviewedGenomics

A single cell framework for multi-omic analysis of disease identifies malignant regulatory signatures in mixed phenotype acute leukemia

Jeffrey M. Granja, Sandy L. Klemm, Lisa M. McGinnis, Arwa S. Kathiria, Anja Mezger, Benjamin E. Parks, Eric J. Gars, Michaela Liedtke, Grace X. Y. Zheng, Howard Y. Chang, Ravindra Majeti, William James Greenleaf

This paper develops a single-cell multi-omic framework to identify malignant regulatory signatures in mixed phenotype acute leukemia by analyzing transcriptomic and epigenetic data.

bioRxiv · Jul 9, 2019 · PreprintGenomics

High-throughput chromatin accessibility profiling at single-cell resolution

Anja Mezger, Sandy L. Klemm, Ishminder K. Mann, Kara K. Brower, Alain A. Mir, Magnolia L. Bostick, Andrew A. Farmer, Polly Morrell Fordyce, Sten Linnarsson, William James Greenleaf

The paper develops a high-throughput single-cell ATAC-seq method and applies it to cluster PBMCs by hematopoietic cell type.

Nature Communications · Sep 3, 2018Peer-reviewedGenomics