Zhaowei Yang

The paper establishes reference samples with high-coverage whole-genome sequencing to create truth sets for somatic mutation and germline variant detection using NGS technologies.

This study benchmarks seven SARS-CoV-2 whole-genome sequencing protocols using patient samples, finding performance differences based on viral input and sequencing parameters.

This study evaluates somatic CNV callers using NGS data from 91 samples with varying factors, finding that caller choice and tumor purity significantly impact call quality.

The paper presents a multi-center cross-platform scRNA-seq reference dataset for benchmarking bioinformatics methods across different platforms and centers.

This study benchmarks scRNA-seq reproducibility across platforms and pipelines, finding that batch correction methods significantly affect results.

The paper evaluates epigenetic methods using reference materials, finding high concordance between assays and differences in performance across platforms.