Protein domain characterization reveals human MIC60 tolerates loss of helical bundle domain
Stephanie Rockfield, Krishnan Venkataraman, Chih-Hsuan Wu, Randall Wakefield, Alan Wu, Amit Budhraja, Ricardo Rodriguez-Enriquez, Ali Khalighifar, Camenzind G. Robinson, Cai Li, Alexandre F. Carisey, Joseph T. Opferman
The paper identifies that the helical bundle domain of human MIC60 is dispensable for its core functions, revealing unexpected modularity in MICOS organization.
bioRxiv · Mar 24, 2026 · PreprintCell Biology