Author

Amit Budhraja

St. Jude Children's Research HospitalORCID 0000-0002-4216-8608Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1 Organism:mouse· 1

Frequent Co-Authors

Joseph T. OpfermaniD· 2 shared Alan Wu· 1 shared Alexandre F. CariseyiD· 1 shared Ali KhalighifariD· 1 shared Cai LiiD· 1 shared Camenzind G. RobinsoniD· 1 shared Chih-Hsuan Wu· 1 shared Dennis VoroniniD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersCancer Biology

Joseph T. OpfermanORCID

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2 papers

Recent·Most cited

Cancer BiologyCell Death and DiseasePeer-reviewedJun 25, 2026

Mitochondrial Integrated Stress Response Activation Creates a Therapeutic Vulnerability to MCL-1 Inhibition in Acute Myeloid Leukemia

Lauren Brakefield, Amit Budhraja, Peter A. Hall…·Joseph T. Opferman

This study identifies co-targeting of MCL-1 and ETC complex I as a synergistic therapy for high-risk AML, showing improved viability reduction and survival in preclinical models.

DOI 10.1038/s41419-026-09037-w

humanbulk RNA-seq

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Cell BiologybioRxivPreprintMar 24, 2026

Protein domain characterization reveals human MIC60 tolerates loss of helical bundle domain

Stephanie Rockfield, Krishnan Venkataraman, Chih-Hsuan Wu…·Joseph T. Opferman

The paper identifies that the helical bundle domain of human MIC60 is dispensable for its core functions, revealing unexpected modularity in MICOS organization.

1 citation

mouseexperimental assay

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