Author

Chih-Hsuan Wu

St. Jude Children's Research Hospital

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 1 Cell Biology· 1 Genetic & Genomic Medicine· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

Cai LiiD· 3 shared Abbas ShirinifardiD· 1 shared Alan Wu· 1 shared Alexandre F. CariseyiD· 1 shared Ali KhalighifariD· 1 shared Amit BudhrajaiD· 1 shared Camenzind G. RobinsoniD· 1 shared Danielle R. LittleiD· 1 shared

Activity by Year

2024-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersGenetic & Genomic Medicine

Cai LiORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Prevalence and Clinical Significance of Adult-Onset Cancer Predisposition Variants in Pediatric Oncology

Jamie L. Maciaszek, Victor Pastor Loyola, Taylor Cain, Maria F. Cardenas, Patrick R. Blackburn, Mark R. Wilkinson, Selene C. Koo, Chih-Hsuan Wu, Cai Li, Lu Wang, Kim E. Nichols, Jeffery M. Klco, Mohammad K. Eldomery

The paper examines the prevalence and clinical significance of adult-onset cancer predisposition variants in pediatric cancer patients, finding most variants are secondary rather than directly related to the tumor.

medRxiv · Jun 8, 2026 · PreprintGenetic & Genomic Medicine

Protein domain characterization reveals human MIC60 tolerates loss of helical bundle domain

Stephanie Rockfield, Krishnan Venkataraman, Chih-Hsuan Wu, Randall Wakefield, Alan Wu, Amit Budhraja, Ricardo Rodriguez-Enriquez, Ali Khalighifar, Camenzind G. Robinson, Cai Li, Alexandre F. Carisey, Joseph T. Opferman

The paper identifies that the helical bundle domain of human MIC60 is dispensable for its core functions, revealing unexpected modularity in MICOS organization.

bioRxiv · Mar 24, 2026 · PreprintCell Biology

Crop-OCT: a Fully Integrated Imageomics Pipeline to Identify Regional and Focal Retinopathy in Murine Models

Danielle R. Little, Abbas Shirinifard, Marybeth S. Lupo, Chih-Hsuan Wu, Haoran Chen, Mellisa R. Clemons, Michael MacLean, Olivia J. Marola, Gareth R. Howell, Cai Li, Michael A. Dyer

Crop-OCT is an automated pipeline for analyzing OCT images to identify retinopathy in murine models, enabling the detection of regional and focal lesions across multiple diseases.

bioRxiv · Mar 2, 2026 · PreprintNeuroscience

The curses of performing differential expression analysis using single-cell data

Chih-Hsuan Wu, Xiang Zhou, Mengjie Chen

This paper identifies four major challenges in single-cell differential expression analysis and proposes a novel paradigm to address them.

bioRxiv · May 28, 2024 · PreprintBioinformatics