m5C RNA Methylation Is Dysregulated by Oncogenic Herpesviruses via c-Myc Signaling to Counteract Host Antiviral Factors
Zhenyu Wu, Yan Liu, Dawei Zhou, Zhixian He, Guillaume N. Fiches, Youngmin Park, Alan Zhu, Jinshan He, Jianwen Chen, K.A.S.N. Shanaka, Thurbu Tshering Lepcha, Prashant Desai, Jian Kang Zhu, Netty G. Santoso
This study shows that KSHV and EBV reduce host m5C RNA methylation via c-Myc to destabilize TRIM25 and promote lytic replication.
Nucleic Acids Research · Mar 19, 2026Peer-reviewedMicrobiology