A CK2α-G3BP1 signaling axis regulates local translation in developing neurons and is disrupted in OCNDS
Manasi Agrawal, Meghal Desai, Shruti Ghumra, Yashashree Bhorkar, Brandon J. Vaglio, Kyle Stokes, Krishna Rana, Ny-Ziah Hamilton Hill, Peace Nweze, Nethra Sriram, Alana LoRe, Riki Kawaguchi, Bonnie L. Firestein, Jack M. Parent, Daniel H. Geschwind, , Pabitra Kumar Sahoo
This study identifies a CK2α-G3BP1 signaling axis critical for neuronal translation and development, showing its disruption causes OCNDS pathology.
bioRxiv · Aug 19, 2026 · PreprintNeuroscience